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The Effects of Prehabilitative Exercise on Functional Recovery Following Total Knee Arthroplasty

September 9, 2019


The Carilion Clinic is hosting a clinical trial that measures how pre-surgery exercise, known as Prehabilitation, may improve recovery in Total Knee Arthroplasty (TKA) patients after surgery. Improvements are measured using the 6-minute walk (6MW) test. Additionally, Change of Manual muscle tests (hip flexion, extension, abduction; knee flexion, extension and ankle dorsiflexion) over time using the MicroFET2 and Change of Knee Injury and Osteoarthritis Outcome Score (KOOS) over time using a questionnaire are measured. 


Study Information

This study will place patients in one of two groups at random: an experimental arm group with an intervention and a control arm group. Prehabilitation exercise will serve as the intervention for the experimental arm group. Patients in this group will participate in a prehabilitation exercise program three times a week for eight weeks. Usual standard of care will be used in the control arm group. This includes written home exercise program for strength and flexibility provided during a total joint education pre-surgery class.


Inclusion Criteria

  • All sexes, ages 50 to 85 years old
  • Those waiting on primary unilateral total knee arthroplasty for knee osteoarthritis
  • agree to participate in study and complete a guided exercise program three times per week for eight weeks


Exclusion Criteria

  • Currently use tobacco 
  • Body mass index (BMI) greater than 40 kg/m2
  • Pain in the contralateral limb of 5/10 or more while climbing stairs
  • Those who had knee or hip replacement surgery in the last year
  • Any medical conditions that prevent regular exercise
  • Any disease that affects functional performance such as Stroke or Parkinson’s disease



You may participate in this study at the Institute for Orthopaedics and Neurosciences in Roanoke, Virginia, United States, 24014. If you have any questions or concerns, please contact Kathy Chalflinch, DNP at (540) 853-0461 or at You may also contact Deborah F. Joyce at 540-588-0604 or at



This study is sponsored by the Carilion Clinic and collaborated by Radford University. William H. Kolb, DPT of Radford University serves as the Principal Investigator.

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